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Background: Anogenital distance AGD is an androgen responsive anatomic measurement that may have ificant utility in clinical and epidemiological research studies. We describe development of standardized measurement methods and predictors of AGD outcomes.

We developed and implemented a detailed training protocol that incorporated multiple quality control QC measures. We used the intra-rater ICC to assess within-examiner variability and the inter-rater ICC to assess between-examiner variability. We used multivariable linear regression to examine predictors of AGD outcomes including: gestational age at birth, birth weight, gestational age, several measures of body size, race, maternal age, and study center.

Conclusions: Our study confirms that with appropriate training and quality control measures, AGD and PW measurements can be performed reliably and accurately in male and female infants. In order for reliable interpretation, these measurements should be adjusted for appropriate covariates in epidemiologic analysis.

Keywords: Anogenital distance; Pediatric; Penile width; Urology. Published by Elsevier Ltd. All rights reserved. Conflict of interest : None. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other penis rater features are temporarily unavailable.

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Abstract Background: Anogenital distance AGD is an androgen responsive anatomic measurement that may have ificant utility in clinical and epidemiological research studies. Conflict of interest statement Conflict of interest : None. Figures Figure 1. Anogenital Distance Measurements and Values…. Figure 1. See this image and copyright information in PMC. Similar articles First trimester phthalate exposure and anogenital distance in newborns.

Swan SH, et al. Hum Reprod. Epub Feb Maternal plasma concentrations of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and anogenital distance in male infants. Tian Y, et al. PMID: Anogenital distance in children born of mothers with polycystic ovary syndrome: the Odense Child Cohort. Glintborg D, et al. Clinical review: Anogenital distance or digit length ratio as measures of fetal androgen exposure: relationship to male reproductive development and its disorders. Dean A, Sharpe RM. Dean A, et al. J Clin Endocrinol Metab. Epub Apr 8.

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PMID: Review. Anogenital distance as a marker of androgen exposure in humans. Thankamony A, et al. Epub Feb 4. See all similar articles. Cited by 20 articles Maternal urinary levels of glyphosate during pregnancy and anogenital distance in penis rater in a US multicenter pregnancy cohort.

Lesseur C, et al. Environ Pollut. Epub Mar O'Connor T, et al. BMJ Open. Digit ratio, a proposed marker of the prenatal hormone environment, is not associated with prenatal sex steroids, anogenital distance, or gender-typed play behavior in preschool age children. Barrett E, et al.

J Dev Orig Health Dis. Online ahead of print. Fischer MB, et al.

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Lyon-Caen S, et al. See all "Cited by" articles. Publication types Research Support, N. Cohort Studies Actions.

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Female Actions. Gestational Age Actions. Humans Actions. Infant Actions. Infant, Newborn Actions. Male Actions. Maternal Age Actions. Predictive Value of Tests Actions. Pregnancy Actions. Reference Values Actions.

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